Cantor Technology released the spreads for every NFL game in Weeks 1-16. Below are the lines for San Francisco's games.
Week 17 is excluded because of high variance caused by potential playoff seeding, QBs sitting out the final week or playing partial games, etc.
Here is the list for every game.
Week 1
Panthers at 49ers (+4.5)
Week 2
49ers (+13) at Seahawks
Week 3 (Thursday)
Rams at 49ers (-1.5)
Week 4
49ers (+9) at Cardinals
Week 5
49ers (+9) at Colts
Week 6
49ers (+8) at Redskins
Week 7
Cowboys at 49ers (+8.5)
Week 8
49ers (+7.5) at Eagles
Week 9
Cardinals at 49ers (+3.5)
Week 10
Giants at 49ers (+4.5)
Week 11
BYE
Week 12
Seahawks at 49ers (+7.5)
Week 13
49ers (+4) at Bears
Week 14
49ers (+9) at Texans
Week 15
Titans at 49ers (+3)
Week 16
Jaguars at 49ers (+1)