Atletico Madrid brushed aside Guijuelo 4-0 to win 10-1 on aggregate in their Copa del Rey round of 32 tie.
Atletico boss Diego Simeone named a strong side and Nicolas Gaitan, Angel Correa, Juanfran and Fernando Torres all scored before half-time.
Antonio Pino managed a consolation for the third-tier minnows.
Malaga suffered a shock exit to their second division neighbours Cordoba.
Juande Ramos' La Liga side were seeking to overturn a 2-0 first-leg deficit, but Cordoba enjoyed an incredible 4-3 away victory to win 6-3 on aggregate.
Sandro twice gave Malaga the lead in the first half, but Federico Piovaccari levelled each time and Pedro Rios' 66th-minute penalty gave Cordoba the lead on the night.
Michael Santos made it 3-3 two minutes from time, but Rios had the final word in the Andalusian derby as Cordoba booked their place in the last 16.
Las Palmas beat Huesca 2-1 to move through to the last 16 with a 4-3 aggregate scoreline.
Mateo Garcia and Asdrubal put Las Palmas in control before Kilian Grant grabbed a stoppage-time consolation.
Real Sociedad also progressed as a 1-1 draw against Real Valladolid secured a 4-2 aggregate win.
Juanmi headed Sociedad into an 11th-minute lead before home defender Mikel Gonzalez put through his own net.
Villarreal also eased through 4-1 on aggregate against Toledo after drawing the home tie 1-1.
Samu Villa raised Toledo hopes of causing an upset, but Alexandre Pato struck three minutes later with his fifth goal of the season.