Leicester will be without captain Wes Morgan against both Everton and Atletico Madrid as the defender continues to nurse a back injury.
Morgan has missed the last three matches and he will remain on the sidelines at Goodison Park on Sunday, as well as sitting out the first leg of the Champions League quarterfinal at the Vicente Calderon next Wednesday.
The 33-year-old has done some light training this week but Yohan Benalouane will continue to deputise at centre-half against Everton.
"Wes Morgan is still out, although he's put his boots on and been on the grass," said Leicester boss Craig Shakespeare.
"It would be a lot to ask him to come back for a game of that magnitude in Madrid. I would want him to do a few training sessions first and at the moment that looks highly unlikely.
"It is a big loss but Yohan [Benalouane] has come in and done well.
"Wes, since I've been here, rarely misses a day's training. It is a new experience. He is still in and around the lads, playing a part off the pitch. He comes in the dressing room, before the game and at half-time. I encourage him to be in and around it."
Asked if he might rest key players against Everton, just three days ahead of the club's first ever Champions League quarter-final, Shakespeare added: "I'll assess the squad over the next 24 hours.
"I'll talk to the staff and I will pick a team who can win the game at Everton. My sole focus is on Everton, not Madrid."
Shakespeare will join Carlo Ancelotti and Pep Guardiola as the only managers to win their first six Premier League games should Leicester win at Goodison Park.
The 53-year-old includes Liverpool and Sevilla among his scalps but he thinks Everton will pose his toughest challenge yet.
He said: "Potentially it is. Ronald Koeman has done a great job. To be a minute away from winning at Old Trafford the other night shows where they are at.
"The idea is to win, and if you can't win you make sure you don't lose. I couldn't have asked for a better start.
"It means more to get three points, rather than records -- which are nice. But it is more about the three points and the team."