Toronto FC defender Drew Moor will be out for up to three months, while Jozy Altidore will miss more than a week with injuries, coach Greg Vanney confirmed on Monday.
Moor suffered a quad tear during training for last week's CONCACAF Champions League final second leg against Chivas.
United States international striker Altidore suffered a mild hamstring issue in the game.
"I don't know the exact timeline [of his return]. It's more along the lines of months than weeks because it's a fairly significant tear," Vanney told reporters regarding Moor's absence.
"It was a moment in training that you never in your lifetime believe he was going to be out for a couple of months given the situation. It was a 10-yard pass that led to him pulling up."
He added: "I don't know exactly [how long he'll be out]. I would put it at the two- to three-month range."