Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the predicted XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All predicted XIs and injury news powered by Rotowire, subject to updates.)
Newcastle United v Arsenal
St. James' Park
Saturday, 8:30 a.m. ET / 12:30 p.m. UK
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Joelinton | CM Bruno Guimaraes | CM Sandro Tonali
FWL Harvey Barnes | ST Alexander Isak | FWR Anthony Gordon
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 4
Anthony Gordon, F/M, undisclosed, DOUBT
Alexander Isak, F, undisclosed, DOUBT
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Jacob Murphy, F/M, hamstring, DOUBT
Matt Targett, D, not injury related, DOUBT
Kieran Trippier, D, undisclosed, OUT, estimated return Nov. 10
Callum Wilson, F, back, OUT, estimated return Nov. 25
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Jurriën Timber | CB William Saliba | CB Ben White | RB Thomas Partey
DM Mikel Merino | DM Declan Rice
LW Gabriel Martinelli | AM Leandro Trossard | RW Bukayo Saka
ST Kai Havertz
Injury/suspension updates:
Riccardo Calafiori, D, knee, OUT, estimated return Nov. 23
Gabriel Magalhaes, D, knee, DOUBT
Martin Ødegaard, F/M, ankle, OUT, estimated return Nov. 10
Kieran Tierney, D, hamstring, OUT, estimated return Nov. 23
Takehiro Tomiyasu, D, knee, DOUBT
Ben White, D, undisclosed, DOUBT
AFC Bournemouth v Manchester City
Vitality Stadium
Saturday, 10 a.m. ET / 2 p.m. UK
Latest AFC Bournemouth team news
Expected Lineup:
GK Mark Travers
LB Milos Kerkez | CB Marcos Senesi | CB Illia Zabarnyi | RB Adam Smith
DM Ryan Christie | DM Lewis Cook
LW Antoine Semenyo | AM Marcus Tavernier | RW Dango Ouattara
ST Evanilson
Injury/suspension updates:
Kepa Arrizabalaga, G, thigh, DOUBT
Philip Billing, M, illness, DOUBT
Alex Scott, M, knee, OUT, estimated return Dec. 21
Luis Sinisterra, F/M, undisclosed, DOUBT
Latest Manchester City team news
Expected Lineup:
GK Ederson
LB Josko Gvardiol | CB Rúben Dias | CB John Stones | RB Rico Lewis
DM Mateo Kovacic
LM Phil Foden | CM Ilkay Gündogan | CM Matheus Luiz Nunes | RM Bernardo Silva
ST Erling Haaland
Injury/suspension updates:
Manuel Akanji, D, strain, DOUBT
Oscar Bobb, F/M, leg, OUT, estimated return Nov. 30
Kevin De Bruyne, F/M, groin, OUT, estimated return Nov. 23
Jérémy Doku, F/M, undisclosed, OUT, estimated return Nov. 5
Jack Grealish, F/M, undisclosed, OUT, estimated return Nov. 23
Rodri, M, knee, OUT, estimated return Jul. 1
Savinho, F/M, strain, DOUBT
Kyle Walker, D, knee, OUT, estimated return Nov. 23
Ipswich Town v Leicester City
Portman Road
Saturday, 10 a.m. ET / 2 p.m. UK
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Luke Woolfenden | RB Dara O'Shea
DM Jens Cajuste | DM Kalvin Phillips
AM Omari Hutchinson | RW Wes Burns
ST George Hirst
Injury/suspension updates:
Harrison Clarke, D, suspension, due back Nov. 10
Jacob Greaves, D, undisclosed, DOUBT
Omari Hutchinson, F/M, illness, DOUBT
Ben Johnson, D, thigh, DOUBT
Massimo Luongo, M, ankle, OUT, estimated return Nov. 24
Sam Morsy, M, hamstring, DOUBT
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Cieran Slicker, G, undisclosed, DOUBT
Axel Tuanzebe, D, hand, OUT, estimated return Nov. 24
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB James Justin | CB Wout Faes | CB Caleb Okoli | RB Ricardo Pereira
DM Wilfred Ndidi | DM Harry Winks
LW Stephy Mavididi | AM Facundo Buonanotte | RW Jordan Ayew
ST Jamie Vardy
Injury/suspension updates:
Hamza Choudhury, M, shoulder, OUT, estimated return Nov. 23
Patson Daka, F, ankle, DOUBT
Fatawu Issahaku, F, groin, DOUBT
Victor Kristiansen, D, groin, DOUBT
Jakub Stolarczyk, G, ankle, OUT, estimated return Nov. 23
Liverpool v Brighton & Hove Albion
Anfield
Saturday, 10 a.m. ET / 2 p.m. UK
Latest Liverpool team news
Expected Lineup:
GK Caoimhín Kelleher
LB Andrew Robertson | CB Ibrahima Konaté | CB Virgil van Dijk | RB Trent Alexander-Arnold
DM Ryan Gravenberch | DM Alexis Mac Allister
LW Cody Gakpo | AM Dominik Szoboszlai | RW Mohamed Salah
ST Darwin Núñez
Injury/suspension updates:
Alisson Becker, G, hamstring, OUT, estimated return Nov. 24
Federico Chiesa, F/M, undisclosed, OUT, estimated return Nov. 24
Harvey Elliott, F/M, foot, OUT, estimated return Nov. 24
Diogo Jota, F, upper body, OUT, estimated return Nov. 24
Latest Brighton & Hove Albion team news
Expected Lineup:
GK Bart Verbruggen
LB Pervis Estupiñán | CB Igor Julio | CB Jan Paul van Hecke | RB Joël Veltman
LM Kaoru Mitoma | CM Carlos Baleba | CM Jack Hinshelwood | RM Yasin Ayari
ST Georginio Rutter | ST Danny Welbeck
Injury/suspension updates:
Lewis Dunk, D, calf, DOUBT
João Pedro, F/M, ankle, DOUBT
Ferdi Kadioglu, M/D, undisclosed, DOUBT
Solly March, F/M, knee, DOUBT
James Milner, M/D, hamstring, DOUBT
Yankuba Minteh, F, groin, DOUBT
Matt O'Riley, M, ankle, DOUBT
Adam Webster, D, hamstring, OUT, estimated return Nov. 23
Nottingham Forest v West Ham United
The City Ground
Saturday, 10 a.m. ET / 2 p.m. UK
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Nicolás Domínguez | DM Ryan Yates
LW Callum Hudson-Odoi | AM Elliot Anderson | RW Anthony Elanga
ST Chris Wood
Injury/suspension updates:
Joao Pedro, F/M, undisclosed, DOUBT
Morgan Gibbs-White, F/M, ankle, DOUBT
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Nov. 23
James Ward-Prowse, M, not injury related, DOUBT
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Emerson | CB Max Kilman | CB Jean-Clair Todibo | RB Aaron Wan-Bissaka
DM Edson Álvarez | DM Guido Rodríguez
LW Crysencio Summerville | AM Lucas Paquetá | RW Jarrod Bowen
ST Michail Antonio
Injury/suspension updates:
Niclas Füllkrug, F, calf, OUT, estimated return Nov. 25
Mohammed Kudus, F/M, suspension, due back Nov. 25
Southampton v Everton
St. Mary's Stadium
Saturday, 10 a.m. ET / 2 p.m. UK
Latest Southampton team news
Expected Lineup:
GK Aaron Ramsdale
LB Ryan Manning | CB Jan Bednarek | CB Taylor Harwood-Bellis | CB Jack Stephens | RB Kyle Walker-Peters
CM Flynn Downes | CM Mateus Fernandes | CM Adam Lallana
ST Cameron Archer | ST Adam Armstrong
Injury/suspension updates:
Gavin Bazunu, G, achilles, OUT, estimated return Jan. 11
Tyler Dibling, M, undisclosed, DOUBT
Flynn Downes, M, undisclosed, DOUBT
Ryan Fraser, F/M, undisclosed, DOUBT
William Smallbone, M, hamstring, OUT, estimated return Nov. 24
Ross Stewart, F, calf, OUT, estimated return Nov. 9
Latest Everton team news
Expected Lineup:
GK Jordan Pickford
LB Vitaliy Mykolenko | CB Jarrad Branthwaite | CB James Tarkowski | RB Ashley Young
DM Abdoulaye Doucouré | DM Idrissa Gueye
LW Iliman Ndiaye | AM Dwight McNeil | RW Jack Harrison
ST Dominic Calvert-Lewin
Injury/suspension updates:
Armando Broja, F, ankle, OUT, estimated return Nov. 9
Abdoulaye Doucouré, F/M, undisclosed, DOUBT
James Garner, M, back, OUT, estimated return Dec. 1
Tim Iroegbunam, M, foot, OUT, estimated return Nov. 23
Dwight McNeil, F/M, knee, DOUBT
Youssef Chermiti, F, foot, OUT, estimated return Nov. 23
Wolverhampton Wanderers v Crystal Palace
Molineux Stadium
Saturday, 12:30 p.m. ET / 4:30 p.m. UK
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK Sam Johnstone
LB Rayan Aït-Nouri | CB Santiago Bueno | CB Craig Dawson | RB Nélson Semedo
CM Tommy Doyle | CM João Gomes | CM Mario Lemina
AM Matheus Cunha | AM Pablo Sarabia
ST Jørgen Strand Larsen
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Hwang Hee-Chan, F, ankle, OUT, estimated return Nov. 9
Sam Johnstone, G, groin, DOUBT
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Mario Lemina, M, calf, DOUBT
Bastien Meupiyou, M/D, undisclosed, OUT, estimated return Nov. 23
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15
Latest Crystal Palace team news
Expected Lineup:
GK Dean Henderson
CB Trevoh Chalobah | CB Marc Guéhi | CB Maxence Lacroix
LM Tyrick Mitchell | CM Daichi Kamada | CM Will Hughes | RM Daniel Muñoz
AM Eddie Nketiah | AM Ismaïla Sarr
ST Jean-Philippe Mateta
Injury/suspension updates:
Cheick Doucoure, M, toe, DOUBT
Eberechi Eze, F/M, hamstring, DOUBT
Matheus França, F/M, groin, DOUBT
Jefferson Lerma, M, hamstring, DOUBT
Chadi Riad, D, knee, OUT, estimated return Nov. 23
Chris Richards, D, hamstring, DOUBT
Adam Wharton, M, groin, DOUBT
Tottenham Hotspur v Aston Villa
Tottenham Hotspur Stadium
Sunday, 9 a.m. ET / 2 p.m. UK
Latest Tottenham Hotspur team news
Expected Lineup:
GK Guglielmo Vicario
LB Destiny Udogie | CB Radu Dragusin | CB Cristian Romero | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Dejan Kulusevski | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Wilson Odobert, F/M, hamstring, OUT, estimated return Nov. 23
Son Heung-Min, F/M, strain, DOUBT
Djed Spence, M/D, groin, DOUBT
Micky van de Ven, D, hamstring, OUT, estimated return Nov. 23
Latest Aston Villa team news
Expected Lineup:
GK Emiliano Martínez
LB Lucas Digne | CB Ezri Konsa | CB Pau Torres | RB Matty Cash
LM Jacob Ramsey | CM Amadou Onana | CM Youri Tielemans | RM John McGinn
AM Morgan Rogers
ST Ollie Watkins
Injury/suspension updates:
Robin Olsen, G, undisclosed, OUT, estimated return Nov. 9
Manchester United v Chelsea
Old Trafford
Sunday, 11:30 a.m. ET / 4:30 p.m. UK
Latest Manchester United team news
Expected Lineup:
GK André Onana
LB Noussair Mazraoui | CB Matthijs de Ligt | CB Lisandro Martínez | RB Diogo Dalot
DM Christian Eriksen | DM Casemiro
LW Alejandro Garnacho | AM Bruno Fernandes | RW Marcus Rashford
ST Rasmus Højlund
Injury/suspension updates:
Toby Collyer, M, undisclosed, DOUBT
Antony, F, ankle, DOUBT
Harry Maguire, D, calf, DOUBT
Kobbie Mainoo, M, knee, DOUBT
Tyrell Malacia, D, knee, OUT, estimated return Nov. 10
Mason Mount, F/M, head, DOUBT
Luke Shaw, D, calf, OUT, estimated return Nov. 10
Leny Yoro, D, foot, OUT, estimated return Nov. 24
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Reece James | CB Levi Colwill | CB Wesley Fofana | RB Malo Gusto
DM Moisés Caicedo | DM Romeo Lavia
LW Pedro Neto | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Jadon Sancho, F/M, not injury related, OUT, estimated return Nov. 10
Fulham v Brentford
Craven Cottage
Monday, 3 p.m. ET / 8 p.m. UK
Latest Fulham team news
Expected Lineup:
GK Bernd Leno
LB Antonee Robinson | CB Joachim Andersen | CB Calvin Bassey | RB Kenny Tete
DM Sander Berge | DM Andreas Pereira
LW Alex Iwobi | AM Emile Smith Rowe | RW Adama Traoré
ST Raúl Jiménez
Injury/suspension updates:
Timothy Castagne, D, hamstring, OUT, estimated return Nov. 23
Sasa Lukic, M, shoulder, OUT, estimated return Nov. 23
Carlos Vinícius, F, undisclosed, DOUBT
Latest Brentford team news
Expected Lineup:
GK Mark Flekken
LB Sepp van den Berg | CB Nathan Collins | CB Ethan Pinnock | RB Mads Roerslev
DM Vitaly Janelt | DM Christian Nørgaard
LW Keane Lewis-Potter | AM Mikkel Damsgaard | RW Bryan Mbeumo
ST Yoane Wissa
Injury/suspension updates:
Kristoffer Ajer, D, foot, DOUBT
Josh Dasilva, M, knee, OUT, estimated return Jan. 14
Rico Henry, M/D, knee, OUT, estimated return Nov. 9
Aaron Hickey, M/D, hamstring, OUT, estimated return May. 18
Igor Thiago, F, knee, OUT, estimated return Nov. 30
Gustavo Nunes, F/M, back, OUT, estimated return Nov. 23