Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the predicted XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All predicted XIs and injury news powered by Rotowire, subject to updates.)
Manchester United v Leicester City
Old Trafford
Sunday, 9 a.m. ET / 2 p.m. UK
Latest Manchester United team news
Expected Lineup:
GK André Onana
LB Noussair Mazraoui | CB Matthijs de Ligt | CB Lisandro Martínez | RB Diogo Dalot
DM Manuel Ugarte | DM Casemiro
LW Marcus Rashford | AM Bruno Fernandes | RW Alejandro Garnacho
ST Rasmus Højlund
Injury/suspension updates:
Amad Diallo, F/M, undisclosed, DOUBT
Harry Maguire, D, calf, OUT, estimated return Nov. 24
Kobbie Mainoo, M, knee, OUT, estimated return Nov. 24
Tyrell Malacia, D, knee, OUT, estimated return Dec. 1
Luke Shaw, D, calf, OUT, estimated return Nov. 24
Leny Yoro, D, foot, OUT, estimated return Nov. 28
Latest Leicester City team news
Expected Lineup:
GK Mads Hermansen
LB Victor Kristiansen | CB Wout Faes | CB Jannik Vestergaard | RB James Justin
DM Wilfred Ndidi | DM Harry Winks
LW Stephy Mavididi | AM Facundo Buonanotte | RW Fatawu Issahaku
ST Jamie Vardy
Injury/suspension updates:
Hamza Choudhury, M, shoulder, OUT, estimated return Nov. 23
Patson Daka, F, ankle, OUT, estimated return Nov. 23
Bobby De Cordova-Reid, F/M, lower leg, DOUBT
Jakub Stolarczyk, G, ankle, OUT, estimated return Nov. 23
Nottingham Forest v Newcastle United
The City Ground
Sunday, 9 a.m. ET / 2 p.m. UK
Latest Nottingham Forest team news
Expected Lineup:
GK Matz Sels
LB Álex Moreno | CB Murillo | CB Nikola Milenkovic | RB Ola Aina
DM Nicolás Domínguez | DM Ryan Yates
LW Callum Hudson-Odoi | AM Morgan Gibbs-White | RW Anthony Elanga
ST Chris Wood
Injury/suspension updates:
Danilo Oliveira, M, ankle, OUT, estimated return Dec. 21
Ibrahim Sangaré, M, thigh, OUT, estimated return Nov. 23
Latest Newcastle United team news
Expected Lineup:
GK Nick Pope
LB Lewis Hall | CB Dan Burn | CB Fabian Schär | RB Valentino Livramento
CM Bruno Guimaraes | CM Sandro Tonali | CM Joe Willock
FWL Joelinton | ST Alexander Isak | FWR Anthony Gordon
Injury/suspension updates:
Sven Botman, D, knee, OUT, estimated return Dec. 4
Jamaal Lascelles, D, knee, OUT, estimated return Jan. 15
Jacob Murphy, F/M, hamstring, DOUBT
Matt Targett, D, not injury related, OUT, estimated return Nov. 25
Kieran Trippier, D, hamstring, OUT, estimated return Nov. 25
Callum Wilson, F, back, OUT, estimated return Nov. 25
Tottenham Hotspur v Ipswich Town
Tottenham Hotspur Stadium
Sunday, 9 a.m. ET / 2 p.m. UK
Latest Tottenham Hotspur team news
Expected Lineup:
GK Guglielmo Vicario
LB Destiny Udogie | CB Radu Dragusin | CB Cristian Romero | RB Pedro Porro
CM Dejan Kulusevski | CM Rodrigo Bentancur | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Brennan Johnson
Injury/suspension updates:
Richarlison, F, hamstring, OUT, estimated return Nov. 28
Mikey Moore, F/M, illness, OUT, estimated return Nov. 23
Wilson Odobert, F/M, hamstring, OUT, estimated return Nov. 23
Cristian Romero, D, foot, DOUBT
Djed Spence, M/D, groin, OUT, estimated return Nov. 23
Micky van de Ven, D, hamstring, OUT, estimated return Nov. 23
Timo Werner, F/M, groin, OUT, estimated return Nov. 23
Latest Ipswich Town team news
Expected Lineup:
GK Aro Muric
LB Leif Davis | CB Cameron Burgess | CB Dara O'Shea | RB Ben Johnson
DM Jens Cajuste | DM Sam Morsy
AM Conor Chaplin | RW Omari Hutchinson
ST Liam Delap
Injury/suspension updates:
Jacob Greaves, D, hamstring, OUT, estimated return Nov. 24
Chiedozie Ogbene, F/M, achilles, OUT, estimated return May. 3
Kalvin Phillips, M, suspension, due back Nov. 24
Cieran Slicker, G, undisclosed, OUT, estimated return Nov. 24
Jack Taylor, M, undisclosed, OUT, estimated return Nov. 24
Axel Tuanzebe, D, hand, OUT, estimated return Nov. 24
Chelsea v Arsenal
Stamford Bridge
Sunday, 11:30 a.m. ET / 4:30 p.m. UK
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Levi Colwill | CB Wesley Fofana | RB Reece James
DM Moisés Caicedo | DM Enzo Fernández
LW Pedro Neto | AM Cole Palmer | RW Noni Madueke
ST Nicolas Jackson
Injury/suspension updates:
Cole Palmer, F/M, knee, DOUBT
Jadon Sancho, F/M, illness, DOUBT
Latest Arsenal team news
Expected Lineup:
GK David Raya
LB Jurriën Timber | CB Gabriel Magalhaes | CB William Saliba | RB Ben White
DM Declan Rice | DM Thomas Partey
LW Gabriel Martinelli | AM Leandro Trossard | RW Bukayo Saka
ST Kai Havertz
Injury/suspension updates:
Riccardo Calafiori, D, knee, OUT, estimated return Nov. 23
Kai Havertz, F/M, forehead, DOUBT
Declan Rice, M, toe, DOUBT
Kieran Tierney, D, hamstring, OUT, estimated return Nov. 23
Takehiro Tomiyasu, D, knee, OUT, estimated return Nov. 23