Find out who is missing through injury, who's in a race against time to prove their fitness and who has been ruled out through suspension for the next round of Premier League fixtures.
And as you plan your fantasy team for the next gameweek, check out the Expected XIs for all 20 clubs.
Positions: Goalkeeper (GK), Defender (D), Left-back (LB), Right-back (RB), Centre-back (CB), Midfielder (M), Defensive midfield (DM), Central midfield (CM), Left midfield (LM), Right midfield (RM), Attacking midfield (AM), Left winger (LW), Right winger (RW), Forward (F), Left forward (FWL), Right forward (FWR), Striker (ST)
(All Expected XIs and injury news powered by Rotowire, subject to updates.)
Tottenham Hotspur v Chelsea
Tottenham Hotspur Stadium
Sunday, 4:30 p.m. GMT / 11:30 a.m. ET
Latest Tottenham Hotspur team news
Expected Lineup:
GK Fraser Forster
LB Destiny Udogie | CB Radu Dragusin | CB Archie Gray | RB Pedro Porro
CM James Maddison | CM Yves Bissouma | CM Pape Matar Sarr
FWL Son Heung-Min | ST Dominic Solanke | FWR Dejan Kulusevski
Injury/suspension updates:
Rodrigo Bentancur, M, suspension, due back Dec. 26
Ben Davies, D, undisclosed, DOUBT
Richarlison, F, hamstring, OUT, estimated return Dec. 15
Mikey Moore, F/M, illness, OUT, estimated return Dec. 12
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, foot, DOUBT
Micky van de Ven, D, hamstring, OUT, estimated return Dec. 26
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
Latest Chelsea team news
Expected Lineup:
GK Robert Sánchez
LB Marc Cucurella | CB Levi Colwill | CB Axel Disasi | RB Moisés Caicedo
DM Enzo Fernández | DM Romeo Lavia
LW Jadon Sancho | AM Cole Palmer | RW Pedro Neto
ST Nicolas Jackson
Injury/suspension updates:
Wesley Fofana, D, hamstring, OUT, estimated return Dec. 22
Reece James, D, hamstring, OUT, estimated return Jan. 4
Mykhailo Mudryk, F/M, illness, DOUBT
West Ham United v Wolverhampton Wanderers
London Stadium
Monday, 8 p.m. GMT / 3 p.m. ET
Latest West Ham United team news
Expected Lineup:
GK Lukasz Fabianski
LB Emerson | CB Max Kilman | CB Konstantinos Mavropanos | RB Aaron Wan-Bissaka
DM Lucas Paquetá | DM Tomás Soucek
LW Mohammed Kudus | AM Carlos Soler | RW Jarrod Bowen
ST Danny Ings
Injury/suspension updates:
Michail Antonio, F, undisclosed, OUT, estimated return Jan. 4
Danny Ings, F, undisclosed, DOUBT
Jean-Clair Todibo, D, undisclosed, DOUBT
Latest Wolverhampton Wanderers team news
Expected Lineup:
GK José Sá
LB Rayan Aït-Nouri | CB Santiago Bueno | CB Toti Gomes | RB Nélson Semedo
DM João Gomes | DM Mario Lemina
LW Rodrigo Gomes | AM Matheus Cunha | RW Hwang Hee-Chan
ST Jørgen Strand Larsen
Injury/suspension updates:
Enso Gonzalez, F/M, knee, OUT, estimated return May. 3
Sasa Kalajdzic, F, knee, OUT, estimated return Jan. 15
Yerson Mosquera, D, knee, OUT, estimated return Aug. 15
Boubacar Traoré, M, knee, OUT, estimated return Jan. 15