It seems a long time ago since rivals Arsenal and Tottenham last met in September, with Mikel Arteta's side emerging a 1-0 victors and keeping pace at the top of the Premier League after four games.
Much has happened since. Arsenal remain in the hunt for the Premier League title, although they must close the gap to leaders Liverpool. Any pressure to do so grew even more on Sunday when their exit from the FA Cup put an end to one of their chances for a trophy this season.
Meanwhile, Spurs face issues of their own. Ange Postecoglou's side are without a win in four games in the Premier League. A win in the Carabao Cup semifinal first leg over Liverpool will have lifted spirits, but that was followed by needing extra-time to beat non-league Tamworth.
Here's everything you need to know ahead of the North London Derby.
Key details:
Date: Wednesday, Jan. 15 at 8 p.m. GMT (3 p.m. ET).
Venue: Emirates Stadium, London
Referee: Simon Hooper
VAR: Peter Bankes
How to watch:
The match is available to watch on TNT Sports in the UK and on USA Network (NBC) in the United States. You can also follow live updates on ESPN.
Team news:
Arsenal
Gabriel Jesus, F, knee, OUT, estimated return N/A
Ethan Nwaneri, M, strain, OUT, estimated return Jan. 25
Bukayo Saka, F/M, hamstring, OUT, estimated return Mar. 8
Takehiro Tomiyasu, D, knee, OUT, estimated return Jan. 25
Ben White, D, knee, OUT, estimated return Jan. 15
Tottenham
Rodrigo Bentancur, M, concussion, OUT, estimated return Jan. 26
Ben Davies, D, hamstring, OUT, estimated return Jan. 26
Richarlison, F, hamstring, OUT, estimated return Jan. 19
Destiny Udogie, D, hamstring, OUT, estimated return Feb. 25
Fraser Forster, G, illness, DOUBT
Wilson Odobert, F/M, hamstring, OUT, estimated return Feb. 15
Cristian Romero, D, quadriceps, OUT, estimated return Jan. 19
Micky van de Ven, D, hamstring, OUT, estimated return Jan. 26
Guglielmo Vicario, G, ankle, OUT, estimated return Feb. 25
Expected lineups:
Arsenal
GK David Raya
LB Riccardo Calafiori | CB Gabriel Magalhães | CB William Saliba | RB Jurriën Timber
CM Martin Ødegaard | CM Mikel Merino | CM Declan Rice
FWL Gabriel Martinelli | ST Kai Havertz | FWR Leandro Trossard
Tottenham
GK Antonin Kinsky
LB Djed Spence | CB Radu Dragusin | CB Archie Gray | RB Pedro Porro
DM Lucas Bergvall | DM Pape Matar Sarr
LW Son Heung-Min | AM Dejan Kulusevski | RW Brennan Johnson
ST Dominic Solanke
Stats:
Stats to be provided by ESPN Global Research.
Latest news and analysis:
- Mikel Arteta on Gabriel Jesus injury: 'It's not looking good'
Mikel Arteta has said that the injury that caused Gabriel Jesus to depart Arsenal's FA Cup third-round defeat against Manchester United on a stretcher is "not looking good."
- Ange Postecoglou understands Tamworth's replay frustration
Ange Postecoglou was pleased with Tottenham Hotspur's eventual 3-0 extra-time win over Tamworth in the FA Cup third round on Sunday, but understands why some are frustrated that despite the non-league side holding his Premier League giants after 90 minutes, the new format of the tournament has prevented Tamworth from having a money-spinning replay.
- Arsenal vs Man Utd: Mikel Arteta dubs loss 'one in a thousand'
Mikel Arteta has described Arsenal's FA Cup third-round defeat to Manchester United as a "one in a thousand" occurrence after losing in a dramatic penalty shootout at Emirates Stadium.