The game between No. 2 Louisville and Virginia scheduled for Sunday has been postponed, the Atlantic Coast Conference said Wednesday.
The announcement came amid positive COVID-19 tests, quarantining and contact tracing for the host Cavaliers.
In addition, the Cardinals' game against visiting North Carolina has been rescheduled for Tuesday. That game was originally postponed from Dec. 13 due to coronavirus issues within the Louisville program and later rescheduled for Friday, though it was pushed back again due to what the league described as travel-logistics issues for the Tar Heels.
Louisville also announced Thursday that it has added two games against nearby opponents. The Cardinals will host Northern Kentucky at 3 p.m. ET Friday and Bellarmine at noon ET Saturday in a game that was originally scheduled for Dec. 6.
Also, the Cardinals' game against Pittsburgh, scheduled for Jan. 7, has been postponed because of a positive COVID-19 test in the Panthers' program.
Louisville hasn't played a game since a 73-49 victory over Duke on Dec. 9. The Cardinals later paused all team-related activities after there was a positive COVID-19 test within their program, while the Blue Devils decided to end their season due to safety concerns.
The Associated Press contributed to this report.