GLENDALE, Ariz. -- Despite one of Kyler Murray's most impressive runs of his young career, Sunday's 26-23 loss to the Detroit Lions included some of his worst play in the NFL.

The Arizona Cardinals quarterback and reigning Rookie of the Year threw three interceptions -- and came close to a fourth -- and was able to run for just 29 yards, after averaging 79 rushing yards in his first two games.

While Murray's performance wasn't what lost the game, his three picks led to 10 Lions points, all of which were scored after Murray turned the ball over deep in Arizona territory.

It was Murray's fourth multi-interception game of his career, which consists of just 19 games.

He finished the game with 270 yards, two touchdowns and three interceptions on 23-for-35 passing. Through three games, Murray's touchdown-to-interception ratio is 4-to-5.

Buy/sell on a breakout performance: Buy on Andy Isabella. The second-year receiver set a career high with two touchdowns, showing not only his Year 2 jump but also that he can be a key cog in the Cardinals' passing game and not just in their rushing attack. Isabella has the speed and quickness to get the necessary separation as well as the slipperiness to get out of defenders' grasp.

Troubling trend: The ups and downs of the Cardinals' defense didn't help offset the offensive woes. For as many big third-down stops or red zone holds as the defense made, it gave up chunk plays that allowed the Lions to hang around.

QB breakdown: Murray was flagged for intentional grounding late in the second quarter, stunting any chance of a last-second scoring effort. But there were times when Murray looked spectacular, like on a 1-yard touchdown run in which he juked Lions rookie cornerback Jeff Okudah three times and dove in for a touchdown, and threw a beautiful rainbow pass to Isabella on a corner fade for a touchdown.

Silver lining: Wide receiver DeAndre Hopkins finished with 137 yards on 10 catches, giving him 358 yards on the season. It's the most through the first three games of his career and puts Hopkins -- who has five 1,000-yard seasons, including two 1,500-yard efforts -- on pace for 1,909 yards this season.