Week 1 was one of the best underdog weeks in recent history. Underdogs went 12-4 ATS, the most underdog covers in Week 1 in the Super Bowl era. Underdogs had nine outright wins, tied for the most in Week 1 in that span.
This week, three teams are double-digit favorites, the most in a single week this early in the season since 2009. That includes the Green Bay Packers, who are coming off a blowout loss against the New Orleans Saints. The Packers are 6-0 outright and ATS coming off a loss under Matt LaFleur.
There are also six divisional games, including the Thursday and Monday games. Recently, backing divisional underdogs early in the season has been extremely profitable. Since 2006, underdogs in division games are covering at nearly a 62 percent clip within the first three weeks of the season.
New York Giants at Washington Football Team (-3.5), Thursday, 8:20 ET
New York is 5-12 ATS in September since 2017 and 9-19-1 ATS since 2013.
Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616). New York is 16-4 ATS as a road underdog since the start of the 2018 season.
New York is also 18-6 ATS on the road over that same span. Daniel Jones is 8-2 ATS in his career as a road underdog and 9-4 ATS on the road. New York is 3-0 ATS in games with fewer than 6 days of rest under Joe Judge.
New York is 5-1 ATS against the NFC East under Joe Judge. New York is 13-3-1 to the under with Joe Judge as coach, the highest under percentage in the NFL.
Daniel Jones is 4-0 outright against Washington (3-1 ATS) and 4-19 SU against all other teams.
Cincinnati Bengals at Chicago Bears (-3), Sunday, 1 ET
Chicago is 4-11 ATS following a straight-up loss over the past three seasons.
Chicago has failed to cover each of its past three games as a home favorite. It is also 2-8 ATS over its past 10 as a favorite.
Cincinnati has won just one of its past 16 road games straight up (1-14-1 SU, 8-8 ATS) under Zac Taylor.
Houston Texans at Cleveland Browns (-12.5), Sunday, 1 ET
Cleveland has not been at least a 12-point favorite since Week 8 of 1995, its final season before moving to Baltimore.
This will be just the 4th time that the Browns have been double-digit favorites since 2000. That's the 2nd-fewest such games in the NFL over that span (Lions - 3). Cleveland is 2-1 ATS in that spot.
Tyrod Taylor has covered his last six starts including the playoffs, and he is 5-0 ATS since leaving the Bills after the 2017 season. Houston has covered six straight meetings against Cleveland since 2006.
Houston is the first undefeated team to be a double-digit underdog since Week 2 of 2016 when San Francisco was a 13-point underdog in Carolina.
Los Angeles Rams (-4) at Indianapolis Colts, Sunday, 1 ET
Los Angeles is 10-4-1 ATS in games in September since Sean McVay became head coach in 2017.
Sean McVay is 38-26-2 ATS in his career (regular season).
Indianapolis is 0-4 ATS as a home underdog under Frank Reich.
The under is 25-16 in Carson Wentz starts since 2018 including the playoffs, and the under has hit in seven straight games.
Carson Wentz is 7-4 ATS has a home underdog in his career (0-1 with Indianapolis).
This is the first time Matthew Stafford has been favored by more than a field goal on the road since Week 16 of 2014.
Buffalo Bills (-3) at Miami Dolphins, Sunday, 1 ET
Buffalo games have gone 13-6-1 to the over since the start of last season (0-1 this season).
Miami is 16-5 ATS in its last 21 games as an underdog with five straight covers. Tua Tagovailoa is 4-0 ATS as an underdog.
Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616).
Miami is 12-5 ATS since the start of last season, the best cover percentage in the NFL over that span.
Josh Allen is 11-4-1 ATS on the road in his career.
The last four meetings have all gone over the total.
New England Patriots (-5.5) at New York Jets, Sunday, 1 ET
Over the past 10 seasons, New York is 11-7 ATS against New England despite going 2-16 SU. New England has covered five of the last seven meetings and won 10 straight outright.
The under is 27-13 in New England road games since the start of the 2016 season.
New England has failed to cover in five of its past six games as a favorite.
New York is 6-11 ATS since the start of last season, tied for the worst cover percentage in the NFL.
In the last 20 seasons, Bill Belichick is 14-12 ATS against rookie quarterbacks. However, in the first nine weeks of the season, rookie quarterbacks are 9-2 ATS in that span against Belichick. Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616).
San Francisco 49ers (-3.5) at Philadelphia Eagles, Sunday, 1 ET
Kyle Shanahan is 7-17-2 ATS as a favorite in the regular season, including 1-8-1 ATS (6-4 outright) as a favorite of at least seven points.
Philadelphia has covered each of its last five games as a home underdog.
Philadelphia is 3-9 ATS in September since the start of the 2018 season.
Jimmy Garoppolo is 6-10-2 ATS as a favorite since becoming the 49ers' starter.
Las Vegas Raiders at Pittsburgh Steelers (-6), Sunday, 1 ET
Las Vegas has covered four straight games against Pittsburgh.
Ben Roethlisberger is 32-23-2 ATS in his career as a home favorite of 6 or more points.
The Derek Carr/Jon Gruden combination is 5-10 ATS in 1 ET games.
Las Vegas is 14-3 to the over since the start of last season, the highest over percentage in the NFL.
New Orleans Saints (-3) at Carolina Panthers, Sunday, 1 ET
Since the start of the 2018 season, New Orleans is 11-3 ATS when the line falls between -3 and +3. Over that same time span, New Orleans is 18-6 ATS on the road.
New Orleans is also 16-6 ATS as a road favorite since the start of the 2016 season.
New Orleans went 5-1 ATS in divisional games last season.
The over is 10-3 in the last 13 games between these two teams.
Carolina is 8-2 ATS over its past 10 games as an underdog. Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616).
Denver Broncos (-6) at Jacksonville Jaguars, Sunday, 1 ET
Denver was the only team in the NFL last season to be an underdog in every game. It has now been favored in its first two games this season.
Since 2017, Denver is 7-14-2 ATS as a favorite.
Since the start of the 2017 season, Denver is 7-14-2 ATS as a favorite.
Teddy Bridgewater is 35-13 ATS as a starter in the NFL, including 13-7 ATS as a favorite and 4-1 ATS as a road favorite.
Minnesota Vikings at Arizona Cardinals (-4), Sunday at 4:05 ET
Minnesota has covered each of its five games against the Cardinals since the start of the 2011 season.
The over is 8-1 in Minnesota games that follow a loss since the start of last season.
Kirk Cousins is 5-9-1 ATS as a road underdog since becoming the Vikings' starting QB.
Kyler Murray is 2-5 ATS as a home favorite in his career.
Minnesota is 6-11 ATS since the start of last season, tied for the worst cover percentage in the NFL.
Atlanta Falcons at Tampa Bay Buccaneers (-13), Sunday, 4:05 ET
Tom Brady is 201-137-7 ATS in his career including the playoffs (.596).
Tom Brady is 35-31 ATS in his career as a double-digit favorite.
Bruce Arians is 0-4 ATS as a double-digit favorite in his coaching career.
Atlanta has covered seven of its past eight games as a double-digit underdog.
Six straight meetings and nine of the last ten have gone over the total.
Tom Brady is 8-0 SU and 7-1 ATS in his career against Atlanta.
Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616).
Dallas Cowboys at Los Angeles Chargers (-3), Sunday, 4:25 ET
Dak Prescott has gone 1-5 ATS as a starter since the start of last season. Five of his six starts went over the total, including the last five.
Dak Prescott is 14-8-1 ATS as a road underdog in his career.
Los Angeles is 5-14-1 ATS as a home favorite since the start of the 2018 season.
Dallas is 6-11 ATS since the start of last season, tied for the worst cover percentage in the NFL.
Since 2018, games with totals of 55 or higher are 22-14-1 to the under.
Tennessee Titans at Seattle Seahawks (-5.5), Sunday, 4:25 ET
Tennessee has gone 12-4-1 to the over since the start of last season. The over is 21-5-1 in the regular season in Ryan Tannehill starts since he joined the team.
The over is 10-2 in Tennessee's last 12 road games.
Seattle has covered five consecutive September games.
Russell Wilson is 38-29-2 ATS as a home favorite in his career.
Kansas City Chiefs (-3) at Baltimore Ravens, Sunday, 8:20 ET
Since the start of 2018, Baltimore is 9-1 ATS as an underdog. Lamar Jackson is 5-2 outright and 6-1 ATS as an underdog. This is the second time Jackson has been a home underdog - Baltimore beat New England 37-20 as a three-point underdog in 2019, also on Sunday Night Football.
Kansas City has gone 2-10 ATS in its last 12 games dating back to last season including playoffs.
Kansas City is 19-9 ATS in September under Andy Reid (11-3 ATS since 2017 and 8-3 ATS with Patrick Mahomes starting).
Patrick Mahomes is 16-8-1 ATS on the road in his career.
Since 2018, games with totals of 55 or higher are 22-14-1 to the under.
Detroit Lions at Green Bay Packers (-10.5), Monday, 8:15 ET on ESPN
Green Bay is 6-0 ATS following a SU loss under Matt LaFleur.
Green Bay is 6-2 outright and ATS in September under Matt LaFleur, including 3-0 last season (0-1 this season).
Aaron Rodgers is 43-25-2 ATS at home over the past 10 seasons. In his career he is 62-38-2 ATS at home.
Detroit has covered seven of its last eight meetings with Green Bay.
Since 2006, underdogs in division games are 218-144-8 ATS within the first five weeks of the season (.602), including 146-91-7 ATS within the first three weeks (.616).